Nov 10, 2016 Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) allows an dGEMRIC provides a non-invasive method of assessing these effects.
To determine the feasibility of using a high resolution isotropic three‐dimensional (3D) fast T1 mapping sequence for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) to assess osteoarthritis in
We examined the effect of stainless-steel and titanium hardware on dGEMRIC T 1 maps. We tested two strategies to reduce metal artifact in dGEMRIC: (1) saturation recovery (SR) instead of inversion recovery (IR) and (2) applying the metal artifact reduction sequence (MARS), in a gadolinium-doped agarose gel phantom and in vivo with titanium hardware. In the dGEMRIC technique, the negatively charged contrast agent Gd-DTPA 2− (Magnevist, Berlex, NJ) is injected intravenously and diffuses into articular cartilage, with a final concentration inversely proportional to the cartilage GAG concentration 7. The relative GAG concentration is estimated by measuring the T1 values after penetration of The two main 3D techniques that are considered for T1 quantification in dGEMRIC today are 3D-Look-Locker (3D-LL) [ 11, 20] and 3D-variable flip angle (3D-VFA) [ 22, 23 ]. The 3D Look-Locker technique has been validated against the traditional inversion recovery technique. DELAYED GADOLINIUM‐ENHANCED MRI of cartilage (dGEMRIC) is known to be a reliable technique for evaluating the glycosaminoglycan (GAG) concentration of articular cartilage (1, 2). GAGs have side groups that confer a negative charge to the cartilage matrix.
120 p. Technical issues regarding optimization of the dGEMRIC technique for human clinical application have been investigated and reviewed [8, 9]. The dGEMRIC effect depends on the use of a charged gadolinium contrast agent. A non-ionic contrast agent will not be able … Noninvasive techniques are needed for the assessment of the repair tissue. HYPOTHESIS: Magnetic resonance imaging (MRI) with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) can give valuable information regarding the quality and quantity of the repaired cartilage lesion.
The most commonly used contrast agent for the dGEMRIC technique is Magnevist (Bayer Heathcare). Even though the contrast agent Magnevist has been approved for clinical use as an MRI contrast agent, the dGEMRIC technique itself is an off-label application.
Materials and methods. We examined the effect of stainless-steel and titanium hardware on dGEMRIC T 1 maps.
2018-05-16
Question/purpose: In this study, our purpose was to determine the correlation between the relaxation values of three cartilage mapping techniques, dGEMRIC, T1ρ, and T2*, in patients with DDH. @article{342e72fa-4c81-4f53-b7a2-63ac1ef24d30, abstract = {Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo. This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes. Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint cartilage alterations may be problematic.
According to the decrease of glycosaminoglycans in cartilage degeneration, more Gd-DTPA2 penetrates into the cartilage, which will cause a reduction of T1 relaxation time that can be measured in milliseconds - "Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases"
(dGEMRIC) has been shown to be a clinically useful tool for assessing the glycosaminoglycan (GAG) content in cartilage (1–4). Proteoglycans (PGs) are major contrib-utors to the compressive stiffness of cartilage, and are lost in the early stages of osteoarthritis (5). The dGEM-RIC technique measures the T1 relaxation time of car-
The delayed Gadolinium Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC) technique is a well- established method for early assessment of cartilage quality in osteoarthritis.
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120 p. Technical issues regarding optimization of the dGEMRIC technique for human clinical application have been investigated and reviewed [8, 9]. The dGEMRIC effect depends on the use of a charged gadolinium contrast agent. A non-ionic contrast agent will not be able … Noninvasive techniques are needed for the assessment of the repair tissue. HYPOTHESIS: Magnetic resonance imaging (MRI) with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) can give valuable information regarding the quality and quantity of the repaired cartilage lesion.
Although the duration of the total acquisition time (up to 2 hours) diminishes its attractiveness for clinical use, dGEMRIC has potential value in clinical trials, where it has shown the ability to demonstrate changes in morphologically intact cartilage that may be predictive of progression to
The dGEMRIC technique has provided valuable results in studies on hip dysplasia , in comparative studies with arthroscopically determined cartilage softening in early osteoarthritis , and demonstrated the positive effects of moderate exercise on GAG content in knee cartilage . Signal polarity restoration in IR sequence for T1-mapping in the DGEMRIC technique. J. Szumowski1, M. Durkan2, K. Heiles3, D. Brown2, E. Schwarz2, and D. Crawford2 1Radiology, Oregon Health & Science University, Portland, OR, United States, 2Oregon Health & Science University, 3Hewlett-Packard Introduction: Loss of glycosaminoglycan (GAG) in cartilage is typically an initiating event in
2020-12-01
The dGEMRIC technique is a potentially useful clinical imaging method that is currently limited by the long imaging time and need for post‐processing. These limitations are not inherent to the technique but rather are due to the limitations in T1 mapping technique and software.
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2013-07-01 · Using dGEMRIC, such changes can be monitored thereby providing a reliable imaging tool for the evaluation of cartilage quality in the whole joint following cartilage repair. In conclusion, this study demonstrates that the dGEMRIC technique can be used to longitudinally measure changes in T1gd following cartilage repair surgery.
2021-03-19 · The dGEMRIC technique is quite complex because several factors can have influence, among them the body mass index, degree of physical activity, and variations in time between injection of contrast agent and imaging. 66,67 The dGEMRIC technique has provided valuable results in studies on hip dysplasia , in comparative studies with arthroscopically determined cartilage softening in early osteoarthritis , and demonstrated the positive effects of moderate exercise on GAG content in knee cartilage . Modifications in the technique, such as the operation of three-dimensional imaging and dGEMRIC after intra-articular contrast medium administration, have expanded the range of application. dGEMRIC using the Look-Locker technique, Carl Siversson et al, Abstract and oral presentation at International Society for Magnetic Resonance in Medicine (ISMRM) meeting 2008, Toronto, Canada, no 5289 B1 inhomogeneity corrected T1-quantification for dGEMRIC using 3D Look- dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths.
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SCIENTIFIC ARTICLE Using the dGEMRIC technique to evaluate cartilage health in the presence of surgical hardware at 3T: comparison of inversion recovery and saturation recovery approaches
In a study on 30 patients after MACT, with a mean follow-up of 19.61 ± 8.81 months, Trattnig et al. found a mean T1 RT of 427 ± 159 ms and a mean T1 RC of 636 ± 189 ms.